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Chromium Histidine - Mineral/amino acid complex that supports glucose tolerance and weight control for blood sugar levels ranging from high side of normal to a diabetic state. 50 percent better absorption than other forms of chromium. Reference: Agriculture Research Service, Beltsville Human Nutrition Research Center (BHNRC), USDA’s Chief Scientific Research Agency, 2001.
Co-Enzyme Q-10 - Natural antioxidant in the family of substances called Ubiquinones. CoQ10 supports the inhibition of LDL-cholesterol oxidation thought to play a significant role in the pathogenesis of atherosclerosis. CoQ10 is indicated to replace reduced body blood levels of CoQ10 resulting from HMG-CoA reductase inhibitors (Statins) used to treat cholesterol levels. References: Lancet, March, 2003; PDR for Nutritional Supplements 1st Ed., 2001.
Folate (Folate Triglutamate) - A member of the B-vitamin family. It principally converts homocysteine to L-methionine. Elevated homocysteine is associated with cardiovascular and cerebrovascular disease and carotid artery stenosis. Folate Triglutamate appears more effective than the more common monoglutamate (Folic Acid) at protecting the enzymes involved in reducing homocysteine. Reference: PDR for Nutritional Supplements 1st Ed., 2001; Nature, April, 1999. NEJM, 1997.
Glycine Betaine (Trimethylglycine) - Trimethylated compound of the amino acid Glycine. Supports homocysteine conversion to L-methionine. References: Br J Clin Pharmacol, August, 2002; Am Journal Clin. Nutrition, November, 2002.
Hawthorn Berry - The flower and leaf from the fruit bearing shrub Crataegus Oxyacantha supports positive inotropic heart activity and the integrity of the blood vessel wall. They also support the improvement of coronary blood flow, and have positive effects on oxygen utilization. Flavonoids are postulated to account for these effects. Hawthorn has shown promise in the treatment of New York Heart Association (NYHA) functional class II congestive heart failure (CHF) in both uncontrolled and controlled clinical trials. References: Am J Health Syst Pharm., March, 2002; the extract form also supports the inhibition of the accumulation of cholesterol in the liver by enhancing cholesterol degradation to bile acids and by simultaneously suppressing cholesterol biosynthesis. Reference: Atherosclerosis, June, 1996. It also supports the inhibition of platelet aggregation. Reference: N Engl J Med., October, 1986.
L-Arginine - Nitric oxide activity of this amino acid supports the inhibition of vasoconstriction, increase in thrombolytic action, increase in vascular flow and decrease in endothelial inflammation and platelet aggregation. References: PDR for Nutritional Supplements 1st Ed., 2001; Atherosclerosis, 1997.
Lutein with Zeaxanthine - Pigments of the Carotenoid Family. Support protection against phototoxic damage, cataract formation and macular degeneration accelerated by arteriosclerosis. Reference: PDR for Nutritional Supplements 1st Ed., 2001; Invest Ophthalmol Vis Sci., June, 2003.
Magnesium Succinate - Mineral compound supporting normal calcium activity, glucose regulation, inhibition of platelet aggregation and electrical stability of myocardial muscle. Magnesium Succinate appears significantly better absorbed than other Magnesium salt compounds. Reference: PDR for Nutritional Supplements 1st Ed., 2001; Am J Renal Physiol, March, 2000.
Methylcobalamin (B12) - Vitamin coenzyme necessary to assist Folate Triglutamate in converting homocysteine to L-methionine. Reference: Biochemistry, April, 2001 Research supports that Methylcobalamin is utilized more efficiently than the more commonly used cyanocobalamin to assist Folate. Reference: J Lab Clin Med, 1973.
Mixed Tocotrienol Complex - This complex, primarily from Palm Oil (Elaeis guineensis), contains a complete vitamin E mixture. Eight different compounds, four tocopherols (alpha, beta, delta, gamma) and four tocotrienols (alpha, beta, delta, gamma) comprise the Vitamin E family. Natural foods can contain all eight compounds. Most vitamin E supplements contain only alpha-tocopherol. Tocotrienols support regulating HMG Reductase in the synthesis of cholesterol. A mixture supports inhibiting platelet aggregation and low-density lipoprotein oxidation. References; Biochim Biophys Acta, April, 2003; Plant Foods Hum Nutr., 2002; Int J Food Sci Nutr 2000; Free Radic Biol Med, November, 2000.
Oligomeric Proanthocyanidins (OPC) - Natural antioxidant substance derived from pine bark. Positively correlated with vasorelaxation and anti-inflammatory actions. In addition, it supports inhibition of lipid peroxidation, platelet aggregation, capillary permeability, and supports G6PD deficient erythrocytes against haemolytic cell damage and fragility. References: Phytother Res., June, 2003; J Cardiovasc Pharmacol, November, 2002; Altern Med Rev, April, 2000.
Piperine – Major alkaloid of Piper nigrum Linn (Black Pepper Fruits). Supports bioavailability-enhancing activity. Reference: Phytomedicine, April, 2002.
Policosanol - Mixture of (8) long-chain primary aliphatic saturated alcohols derived from the wax of sugar cane. Policosanol administered long term supports the lowering of LDL-C and TC as well as increasing HDL-C levels in young and older patients. This effect occurs in type II hypercholesterolemia without a history of CHD or cerebrovascular disease by inhibiting cholesterol synthesis and absorption and increasing LDL processing and lysis. References: Am J Health Syst Pharm., June, 2003; Med Hypotheses, Sept., 2002; Drugs Aging. 2003; Curr Atheroscler Rep., Jan., 2003; Further, studies support that Policosanol is a phytochemical alternative to classic lipid-lowering agents such as the Statins. Reference: Am Heart J., February, 2002; Angiology, Jan., 2003.
Pyridoxine HCL (B6) - Vitamin that supports lowering of homocysteine and high blood pressure. Pyridoxine HCL also supports antiatherogenic and protective vascular activity. References: JAMA, August, 2002; NEJM, Nov, 2001; Lancet, February, 2000; PDR for Nutritional Supplements 1st Ed., 2001.
